In the last decades, the number of patients receiving chemotherapy has considerably
increased. Given the toxicity of cytotoxic agents to humans (not only for patients but also for …

Cytostatic drugs have been widely used for chemotherapy for decades. However, many of
them have been categorized as carcinogenic, mutagenic and teratogenic compounds …

Methotrexate (MTX) is a folate antagonist drug used for several diseases, such as cancers,
various malignancies, rheumatoid arthritis (RA) and inflammatory bowel disease. Due to its …

Abstract Background Doxorubicin hydrochloride (DOX· HCl), an anthracycline glycoside
antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein …

In recent years, an increasing concern has risen about the presence of pharmaceuticals in
the aquatic environment. Despite their toxicity, increasing consumption and release into the …

The occurrence of 26 commonly used cytostatic compounds in wastewaters was evaluated
using an automated solid-phase extraction (SPE) method with liquid chromatography–high …

The number of patients suffering from cancer is constantly increasing and, consequently, the
number of different chemotherapy treatments administered is increasing. Given the high …

This study reports the use of retention modeling software for the successful method
development of 24 injectable antineoplastic agents. Firstly, a generic screening of several …

Background, aim, and scope According to the high incidence of cancer worldwide, the
amount of cytostatic drugs administered to patients has increased. These compounds are …

Environmental monitoring is usually conducted by surface sampling to detect and quantify
the presence of cytotoxic drugs after their reconstitution and administration. This technique …