Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

SA Dilliard, DJ Siegwart - Nature Reviews Materials, 2023 - nature.com
Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of
medicines that directly reprogramme the central dogma of biology to prevent and treat …

Understanding ligand-protected noble metal nanoclusters at work

MF Matus, H Häkkinen - Nature Reviews Materials, 2023 - nature.com
Ligand-protected noble metal nanoclusters, commonly termed 'monolayer-protected metal
clusters'(MPCs), comprise a common set of structures with an inorganic core stabilized by an …

A translational framework to DELIVER nanomedicines to the clinic

P Joyce, CJ Allen, MJ Alonso, M Ashford… - Nature …, 2024 - nature.com
Nanomedicines have created a paradigm shift in healthcare. Yet fundamental barriers still
exist that prevent or delay the clinical translation of nanomedicines. Critical hurdles …

The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery

W Kim, NK Ly, Y He, Y Li, Z Yuan, Y Yeo - Advanced drug delivery reviews, 2023 - Elsevier
For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

Toxicity of nanomaterials: Exposure, pathways, assessment, and recent advances

P Ganguly, A Breen, SC Pillai - ACS Biomaterials Science & …, 2018 - ACS Publications
Growth in production of manufactured goods and the use of nanomaterials in consumer
products has mounted in the past few decades. Nanotoxicology or toxicity assessment of …

Rational design of polymeric micelles for targeted therapeutic delivery

Y Zheng, Y Oz, Y Gu, N Ahamad, K Shariati… - Nano Today, 2024 - Elsevier
Polymeric micellar drug carriers have emerged as effective tools to enhance the solubility
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …

Understanding cellular interactions with nanomaterials: Towards a rational design of medical nanodevices

F Villanueva-Flores, A Castro-Lugo, OT Ramírez… - …, 2020 - iopscience.iop.org
Biomedical applications increasingly require fully characterized new nanomaterials. There is
strong evidence showing that nanomaterials not only interact with cells passively but also …

[HTML][HTML] Exploring the therapeutic potential of Hibiscus rosa sinensis synthesized cobalt oxide (Co3O4-NPs) and magnesium oxide nanoparticles (MgO-NPs)

MA Khan, F Ali, S Faisal, M Rizwan, Z Hussain… - Saudi Journal of …, 2021 - Elsevier
Herein, we present a green, economic and ecofriendly protocol for synthesis of cobalt oxide
(Co 3 O 4-NPs) and magnesium oxide nanoparticles (MgO-NPs) for multifaceted biomedical …

Protein nanoparticle charge and hydrophobicity govern protein corona and macrophage uptake

SM Pustulka, K Ling, SL Pish… - ACS Applied Materials & …, 2020 - ACS Publications
Protein nanoparticles are biomaterials composed entirely of proteins, with the protein
sequence and structure determining the nanoparticle physicochemical properties. Upon …