Passive mechanical tissue properties are major determinants of myocardial contraction and
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …

Left ventricular hypertrophy (LVH) was one of the earliest studied echocardiographic
characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over …

Left ventricular (LV) systolic wall strain is a new candidate for prognostic indicator of
hypertensive heart failure. It remains unclear how underlying transmural structural …

The lack of a robust pipeline of medical therapeutic agents for the treatment of heart disease
may be partially attributed to the lack of in vitro models that recapitulate the essential …

Cardiovascular diseases (CVDs) affect the myocardium and vasculature, inducing
remodelling of the heart from cellular to whole organ level. To assess their impact at micro …

Key points Diastolic dysfunction in heart failure patients is evident from stiffening of the
passive properties of the ventricular wall. Increased actomyosin interactions may …

The complex and highly organized structural arrangement of some five billion
cardiomyocytes directs the coordinated electrical activity and mechanical contraction of the …

Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of
outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct …

Personalized biophysical modeling of the heart is a useful approach for noninvasively
analyzing and predicting in vivo cardiac mechanics. Three main developments support this …

Hypertension (HTN) is a global health problem and a leading risk factor for cardiovascular
disease (CVD) morbidity and mortality. The hemodynamic overload from HTN causes left …