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Passive myocardial mechanical properties: meaning, measurement, models
Passive mechanical tissue properties are major determinants of myocardial contraction and
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …
Prognostic implications of left ventricular hypertrophy
Left ventricular hypertrophy (LVH) was one of the earliest studied echocardiographic
characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over …
characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over …
Left ventricular strain and transmural distribution of structural remodeling in hypertensive heart disease
Left ventricular (LV) systolic wall strain is a new candidate for prognostic indicator of
hypertensive heart failure. It remains unclear how underlying transmural structural …
hypertensive heart failure. It remains unclear how underlying transmural structural …
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip
The lack of a robust pipeline of medical therapeutic agents for the treatment of heart disease
may be partially attributed to the lack of in vitro models that recapitulate the essential …
may be partially attributed to the lack of in vitro models that recapitulate the essential …
Myocardial mesostructure and mesofunction
The complex and highly organized structural arrangement of some five billion
cardiomyocytes directs the coordinated electrical activity and mechanical contraction of the …
cardiomyocytes directs the coordinated electrical activity and mechanical contraction of the …
Comprehensive analysis of animal models of cardiovascular disease using multiscale x-ray phase contrast tomography
Cardiovascular diseases (CVDs) affect the myocardium and vasculature, inducing
remodelling of the heart from cellular to whole organ level. To assess their impact at micro …
remodelling of the heart from cellular to whole organ level. To assess their impact at micro …
Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness
Key points Diastolic dysfunction in heart failure patients is evident from stiffening of the
passive properties of the ventricular wall. Increased actomyosin interactions may …
passive properties of the ventricular wall. Increased actomyosin interactions may …
Image-based predictive modeling of heart mechanics
Personalized biophysical modeling of the heart is a useful approach for noninvasively
analyzing and predicting in vivo cardiac mechanics. Three main developments support this …
analyzing and predicting in vivo cardiac mechanics. Three main developments support this …
Distinct loading conditions reveal various patterns of right ventricular adaptation
Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of
outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct …
outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct …
Current perspectives on left ventricular geometry in systemic hypertension
Hypertension (HTN) is a global health problem and a leading risk factor for cardiovascular
disease (CVD) morbidity and mortality. The hemodynamic overload from HTN causes left …
disease (CVD) morbidity and mortality. The hemodynamic overload from HTN causes left …