The review is devoted to recent advances in the chemistry of pyridazine—a six-membered
heterocycle containing two nitrogen atoms in adjacent positions. The practical significance …

The promising antitumor effects of progesterone derivatives have been identified in many
studies. However, the specific mechanism of action of this class of compounds has not been …

The present review describes the biological essence of pyridazine scaffold. Around 142
biologically potential pyridazine entities are gathered in a pile from documented literature …

(1) Background: This investigation aimed at develo** a series of c-Met-targeting
cabozantinib-based PROTACs.(2) Methods: Purification of intermediate and target …

Most breast and prostate tumors are hormone-dependent, making it possible to use
hormone therapy in patients with these tumors. The design of effective endocrine drugs that …

Exosomes are small vesicles which are produced by the cells and released into the
surrounding space. They can transfer biomolecules into recipient cells. The main goal of the …

Aim: The study aims to analyze the effect of long-term incubation of ERα-positive MCF7
breast cancer cells with 4-hydroxytamoxifen (HT) on their sensitivity to tubulin polymerization …

An efficient and practical method has been developed for the synthesis of steroidal
imidazoheterocycles via cost-effective and environmentally benign FeCl3-catalyzed …

Heterocyclic derivatives of steroid hormones are potent anticancer agents, which are used in
the chemotherapy of breast and prostate cancers. Here, we describe a novel series of …

A flexible approach to previously unknown spirofused and linked 1, 3, 4-thiadiazine
derivatives of steroids with selective control of heterocyclization patterns is disclosed.(N …