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Insulin granule dynamics in pancreatic beta cells
Glucose-induced insulin secretion in response to a step increase in blood glucose
concentrations follows a biphasic time course consisting of a rapid and transient first phase …
concentrations follows a biphasic time course consisting of a rapid and transient first phase …
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
AJ Morgan, FM Platt, E Lloyd-Evans… - Biochemical …, 2011 - portlandpress.com
Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …
storage cellular compartments with a central role in intracellular Ca2+ signalling …
Structural basis of human KCNQ1 modulation and gating
J Sun, R MacKinnon - Cell, 2020 - cell.com
KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …
GLP‐1 receptor activated insulin secretion from pancreatic β‐cells: mechanism and glucose dependence
AR Meloni, MB DeYoung, C Lowe… - Diabetes, Obesity and …, 2013 - Wiley Online Library
The major goal in the treatment of type 2 diabetes mellitus is to control the hyperglycaemia
characteristic of the disease. However, treatment with common therapies such as insulin or …
characteristic of the disease. However, treatment with common therapies such as insulin or …
Amazing chloride channels: an overview
B Nilius, G Droogmans - Acta Physiologica Scandinavica, 2003 - Wiley Online Library
Aim: This review describes molecular and functional properties of the following Cl–channels:
the ClC family of voltage‐dependent Cl–channels, the cAMP‐activated transmembrane …
the ClC family of voltage‐dependent Cl–channels, the cAMP‐activated transmembrane …
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release
G Krapivinsky, S Mochida, L Krapivinsky, SM Cibulsky… - Neuron, 2006 - cell.com
A longstanding hypothesis is that ion channels are present in the membranes of synaptic
vesicles and might affect neurotransmitter release. Here we demonstrate that TRPM7, a …
vesicles and might affect neurotransmitter release. Here we demonstrate that TRPM7, a …
Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications
ED Burg, CV Remillard… - British journal of …, 2008 - Wiley Online Library
Maintaining the proper balance between cell apoptosis and proliferation is required for
normal tissue homeostasis; when this balance is disrupted, disease such as pulmonary …
normal tissue homeostasis; when this balance is disrupted, disease such as pulmonary …
The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology
There are many reviews of pancreatic acinar cell function and also of pancreatic duct
function, but there is an almost total absence of synthetic reviews bringing the integrated …
function, but there is an almost total absence of synthetic reviews bringing the integrated …