Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects
of neuronal protein trafficking and function. The reversible nature of palmitoylation provides …

Alzheimer's disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

Alzheimer's disease (AD), the most common age-associated dementing disorder, is
pathologically manifested by progressive cognitive dysfunction concomitant with the …

Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and
sphingolipids) are important building blocks of cell membranes, which provide an optimal …

J. Neurochem.(2011) 117, 779–796. Abstract Regulated intramembrane proteolysis (RIP)
controls the communication between cells and the extracellular environment. RIP is …

Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in
cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein …

Sphingolipids in the membranes of neurons play important roles in signal transduction,
either by modulating the localization and activation of membrane-associated receptors or by …

Alzheimer disease is characterized by accumulation of the β-amyloid peptide (Aβ)
generated by β-and γ-secretase processing of the amyloid precursor protein (APP). The …