[HTML][HTML] Role and regulation of autophagy in cancer

R Rakesh, LC PriyaDharshini, KM Sakthivel… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

[HTML][HTML] The PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles

MJ Sanaei, S Razi, A Pourbagheri-Sigaroodi… - Translational …, 2022 - Elsevier
Lung cancer is the leading cause of cancer-related mortality worldwide. Although the
PI3K/Akt/mTOR signaling pathway has recently been considered as one of the most altered …

The hallmarks of flavonoids in cancer

LGS Ponte, ICB Pavan, MCS Mancini, LGS da Silva… - Molecules, 2021 - mdpi.com
Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

New horizons in lung cancer management through ATR/CHK1 pathway modulation

R Thapa, O Afzal, AA Bhat, A Goyal… - Future medicinal …, 2023 - Taylor & Francis
Lung cancer is the leading cause of cancer-related deaths worldwide. Molecular profiling
has contributed to a new classification of lung cancer, driving advancements in research and …

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

A Leonetti, B Wever, G Mazzaschi, YG Assaraf… - Drug Resistance …, 2019 - Elsevier
Immunotherapy has prompted a paradigm shift in advanced non-small cell lung cancer
(NSCLC) treatment, by demonstrating superior efficacy to chemotherapy alone both in …

Autophagy modulation in cancer: current knowledge on action and therapy

M Marinković, M Šprung, M Buljubašić… - … medicine and cellular …, 2018 - Wiley Online Library
In the last two decades, accumulating evidence pointed to the importance of autophagy in
various human diseases. As an essential evolutionary catabolic process of cytoplasmatic …

[HTML][HTML] An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

Z Hu, Y Guan, W Hu, Z Xu, M Ishfaq - Iranian Journal of Basic …, 2022 - ncbi.nlm.nih.gov
The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties
and are mainly found in the roots of Oroxylum indicum (L.) Kurz and Scutellaria baicalensis …

[HTML][HTML] Prognostic implications of autophagy-associated gene signatures in non-small cell lung cancer

Y Liu, L Wu, H Ao, M Zhao, X Leng, M Liu, J Ma… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
Autophagy, a highly conserved cellular proteolysis process, has been involved in non-small
cell lung cancer (NSCLC). We tried to develop a prognostic prediction model for NSCLC …

Resveratrol induces autophagy and apoptosis in non-small-cell lung cancer cells by activating the NGFR-AMPK-mTOR pathway

J Li, Y Fan, Y Zhang, Y Liu, Y Yu, M Ma - Nutrients, 2022 - mdpi.com
Resveratrol (RSV) has been reported to induce autophagy and apoptosis in non-small-cell
lung cancer A549 cells, and the nerve growth factor receptor (NGFR) regulates autophagy …

The influence of circular RNAs on autophagy and disease progression

Y Wang, Y Mo, M Peng, S Zhang, Z Gong, Q Yan… - Autophagy, 2022 - Taylor & Francis
Circular RNAs (circRNAs) are non-coding RNAs that have attracted considerable attention
in recent years. Owing to their distinct circular structure, circRNAs are stable in cells …