The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

▪ Abstract Synaptic transmission is a dynamic process. Postsynaptic responses wax and
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …

Background Transcranial direct current stimulation (tDCS) has been reported to improve
various forms of learning in humans. Stimulation is often applied during training, producing …

It has been known for more than 70 years that synaptic strength is dynamically regulated in a
use-dependent manner. At synapses with a low initial release probability, closely spaced …

Synapse,” intended to contrast our grasp of presynaptic Angleson and Betz (1997) quite
recently reviewed in physiology with our understanding of postsynaptic detail techniques for …

Normal operations of the neocortex depend critically on several types of inhibitory
interneurons, but the specific function of each type is unknown. One possibility is that …

The size of a pool of readily releasable vesicles at a giant brainstem synapse, the calyx of
Held, was probed with three independent approaches. Using simultaneous pre-and …

Calcium ions play crucial signaling roles in many forms of activity-dependent synaptic
plasticity. Recent presynaptic [Ca2+] i measurements and manipulation of presynaptic …

Short-term facilitation is a widely observed form of synaptic enhancement that is not well
understood. Although presynaptic calcium has long been implicated in this process, its role …

Synapses display remarkable alterations in strength during repetitive use. Different types of
synapses exhibit distinctive synaptic plasticity, but the factors giving rise to such diversity are …