Mitochondria are vital to life and provide biological energy for other organelles and cell
physiological processes. On the mitochondrial double layer membrane, there are a variety of …

The human brain is characterised by the most diverse morphological, metabolic and
functional structure among all body tissues. This is due to the existence of diverse neurons …

DNAzyme-based sensors remain at the forefront of metal-ion imaging efforts, but most lack
the subcellular precision necessary to their applications in specific organelles. Here, we …

Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

Parkinson's disease (PD) is characterized by motor symptoms based on a loss of
nigrostriatal dopaminergic neurons and by non-motor symptoms which precede motor …

Fifty years ago, the seminal work by John Olney provided the first evidence of the neurotoxic
properties of the excitatory neurotransmitter glutamate. A process hereafter termed …

Zinc is a highly abundant cation in the brain, essential for cellular functions, including
transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious …

Exploiting zeolitic imidazolate framework (ZIF)-based nanoparticles to synergistically
enhance starvation-combined chemotherapy strategies remains an urgent demand. Herein …

Excitotoxic Ca 2+ accumulation contributes to ischemic neurodegeneration, and Ca 2+ can
enter the mitochondria through the mitochondrial calcium uniporter (MCU) to promote …

The water microbial contamination is very common and different techniques are in practice
for the decontamination purpose. The advance oxidation processes are being employed to …