The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

MQ Lian, WH Chng, J Liang, HQ Yeo… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles
released by both animal and plant cells. These ubiquitous vesicles are involved in …

A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication

YJ Liu, C Wang - Cell Communication and Signaling, 2023 - Springer
Extracellular vesicles (EVs) are small, membrane-bound structures that are released from
cells into the surrounding environment. These structures can be categorized as exosomes …

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

W Zheng, J Rädler, H Sork, Z Niu, S Roudi… - Nature …, 2023 - nature.com
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities.
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …

Extracellular vesicles as personalized medicine

DJ Beetler, DN Di Florio, KA Bruno, T Ikezu… - Molecular aspects of …, 2023 - Elsevier
Extracellular vesicles (EVs) are released from all cells in the body, forming an important
intercellular communication network that contributes to health and disease. The contents of …

Hypoxia induced changes of exosome cargo and subsequent biological effects

H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy

M Van Delen, J Derdelinckx, K Wouters… - Journal of …, 2024 - Wiley Online Library
Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste
disposal vesicle but are an essential part of an intercellular communication system. Besides …

Update on adipose tissue and cancer

KA Brown, PE Scherer - Endocrine reviews, 2023 - academic.oup.com
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Nucleic acid drugs: recent progress and future perspectives

X Sun, S Setrerrahmane, C Li, J Hu, H Xu - Signal Transduction and …, 2024 - nature.com
High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area
of investigation for decades. Currently, most clinically approved therapeutics are small …