Neurons and their connecting axons gradually degenerate in neurodegenerative diseases
(NDs), leading to dysfunctionality of the neuronal cells and eventually their death. Drug …

Herein, we reported novel docetaxel-decorated solid lipid nanoparticle (DCT-SLN)-loaded
dual thermoreversible system (DCT-DRTS) for intramuscular administration with reduced …

The primary focus of the undertaken research was to design and develop poloxamer-based
thermosensitive gel system of escitalopram-loaded nano-structured lipid carriers (ESC …

Revaprazan (REV), a novel reversible Proton Pump Inhibitor (PPI) used to treat peptic
ulcers, faces challenges in therapeutic efficacy due to its poor dissolution properties and a …

Abstract Regorafenib (RG), a multi-targeting kinase inhibitor, has recently been used in the
colorectal cancer (CRC) treatment. However, its clinical effectiveness is severely …

Tacrolimus (TRL) is used for the treatment of atopic dermatitis (AD) due to its T-cell
stimulation effect. However, its significantly poor water solubility, low penetration and …

Purpose The aim of this study was to develop a novel apixaban-loaded solid self-
emulsifying drug delivery system (S-SEDDS) to enhance oral bioavailability. Methods Oils …

Letrozole (LTZ) is used as first-line treatment for hormone-positive breast cancer (BC) in
postmenopausal women. However, its poor aqueous solubility and permeability have …

The aim of this study was to develop paroxetine (PXT) loaded nanotransferosomal gel (PXT-
NTFG) for intranasal brain delivery. The process involved fabricating PXT-NTFs (paroxetine …

The purpose of this study was to enhance the biopharmaceutical performance of
Dexibuprofen (DXI) using transfersomal gel (DXI-TG) as drug delivery system. DXI loaded …