Psychotic depression was initially considered to be at one end of a continuum of severity of
major depression. Subsequent experience demonstrated that psychosis is an independent …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

OBJECTIVE: Selective serotonin reuptake inhibitors are commonly used to treat major
depression; however, the percentage of serotonin (5-HT) transporter (5-HTT) sites occupied …

Presently in the United States, 21 compounds have been approved by the Food and Drug
Administration as antidepressants. Two additional drugs marketed outside the United States …

Seizures are life-threatening adverse drug reactions which are investigated late in drug
development using rodent models. Consequently, if seizures are detected, a lot of time …

An efficient and mild one-pot, gold-catalyzed intramolecular cyclization of N-propargylic β-
enaminones has been achieved for the generation of 1, 4-oxazepine derivatives. This …

Objectives: More than 40 drugs are available to treat affective disorders. Individual selection
of the optimal drug and dose is required to attain the highest possible efficacy and …

Major depression with psychotic features, while fairly common, is frequently misdiagnosed.
Symptoms seen in these patients are those of an overall severe depressive disorder with …

Microbial pathogenesis, cancer progression, and neurological diseases are associated with
oxidative stress due to the increased production of reactive oxygen species (ROS). This …

A general method to construct the scaffolds of dibenzooxazepine and dibenzodiazepine,
through Pd-catalyzed isocyanide insertion and intramolecular C (sp2)–H activation, has …