Regulated proteolysis by ATP-dependent proteases is universal in all living cells. Bacterial
ClpC, a member of the Clp/Hsp100 family of AAA+ proteins (ATPases associated with …

ABSTRACT S. aureus combats cell wall antibiotic stress by altered gene expression
mediated by various environmental signal sensors. In this study, we examined the …

NMR spectroscopy has distinct advantages for providing insight into protein structures, but
faces significant resolution challenges as protein size increases. To alleviate such …

ABSTRACT In Streptococcus thermophilus, the ComRS regulatory system governs the
transcriptional level of comX expression and, hence, controls the early stage of competence …

The MecA-ClpC complex is a bacterial type II AAA+ molecular machine responsible for
regulated unfolding of substrates, such as transcription factors ComK and ComS, and …

Competence for natural DNA transformation is a tightly controlled developmental process in
streptococci. In mutans and salivarius species, the abundance of the central competence …

Regulated proteolysis by ATP-dependent proteases is universal in all living cells. In Bacillus
subtilis, the degradation of the competence transcription factor ComK is mediated by a …

The endospore‐forming Gram‐positive pathogen Bacillus anthracis is responsible for the
usually fatal disease, inhalational anthrax. The success of this pathogen is dependent on its …

In Bacillus subtilis, a proteolytic machine composed of MecA, ClpC and ClpP degrades the
transcription factor ComK, controlling its accumulation during growth. MecA also inhibits …

Efficient protein quality control (PQC) systems are crucial in bacterial cells since they support
adjustments of regulatory processes under changing environmental conditions and are …