Genetics and pathogenesis of Parkinson's syndrome
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
[HTML][HTML] Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …
transmission efficiency depends on the correct functionality and expression of a plethora of …
Synaptopathies: synaptic dysfunction in neurological disorders–A review from students to students
Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …
throughout the nervous system to adjust behavior to environmental stimuli and to control …
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
[HTML][HTML] RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
Recent genome-wide association studies have linked common variants in the human
genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants …
genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants …
An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene–environment interactions
Parkinson's disease (PD) is the second most common neurodegenerative disorder that is
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …
characterized by two major neuropathological hallmarks: the degeneration of dopaminergic …
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
LRRK2 inhibition attenuates microglial inflammatory responses
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's
disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's …
disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's …
The role of the LRRK2 gene in Parkinsonism
JQ Li, L Tan, JT Yu - Molecular neurodegeneration, 2014 - Springer
Abstract Parkinson's disease (PD), like many common age-related conditions, has been
recognized to have a substantial genetic component. Multiple lines of evidence suggest that …
recognized to have a substantial genetic component. Multiple lines of evidence suggest that …
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
Mutations in the LRRK2 gene represent the most common genetic cause of late onset
Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully …
Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully …