Steering research on mRNA splicing in cancer towards clinical translation
Splicing factors are affected by recurrent somatic mutations and copy number variations in
several types of haematologic and solid malignancies, which is often seen as prima facie …
several types of haematologic and solid malignancies, which is often seen as prima facie …
Uncovering the impacts of alternative splicing on the proteome with current omics techniques
The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …
diversification through alternative splicing on the transcriptome. Moreover, the differential …
Accurate isoform discovery with IsoQuant using long reads
Annotating newly sequenced genomes and determining alternative isoforms from long-read
RNA data are complex and incompletely solved problems. Here we present IsoQuant—a …
RNA data are complex and incompletely solved problems. Here we present IsoQuant—a …
SQANTI3: curation of long-read transcriptomes for accurate identification of known and novel isoforms
SQANTI3 is a tool designed for the quality control, curation and annotation of long-read
transcript models obtained with third-generation sequencing technologies. Leveraging its …
transcript models obtained with third-generation sequencing technologies. Leveraging its …
Altered cell and RNA isoform diversity in aging Down syndrome brains
Down syndrome (DS), trisomy of human chromosome 21 (HSA21), is characterized by
lifelong cognitive impairments and the development of the neuropathological hallmarks of …
lifelong cognitive impairments and the development of the neuropathological hallmarks of …
Monitoring the 5′ UTR landscape reveals isoform switches to drive translational efficiencies in cancer
Transcriptional and translational control are key determinants of gene expression, however,
to what extent these two processes can be collectively coordinated is still poorly understood …
to what extent these two processes can be collectively coordinated is still poorly understood …
TAGET: a toolkit for analyzing full-length transcripts from long-read sequencing
Y ** of splicing quantitative trait …
Long read sequencing to reveal the full complexity of a plant transcriptome by targeting both standard and long workflows
O Al-Dossary, A Furtado, A KharabianMasouleh… - Plant Methods, 2023 - Springer
Background Long read sequencing allows the analysis of full-length transcripts in plants
without the challenges of reliable transcriptome assembly. Long read sequencing of …
without the challenges of reliable transcriptome assembly. Long read sequencing of …
Long-read subcellular fractionation and sequencing reveals the translational fate of full-length mRNA isoforms during neuronal differentiation
AJ Ritter, JM Draper, C Vollmers… - Genome Research, 2024 - genome.cshlp.org
Alternative splicing (AS) alters the cis-regulatory landscape of mRNA isoforms, leading to
transcripts with distinct localization, stability, and translational efficiency. To rigorously …
transcripts with distinct localization, stability, and translational efficiency. To rigorously …