The “protein folding problem” consists of three closely related puzzles:(a) What is the folding
code?(b) What is the folding mechanism?(c) Can we predict the native structure of a protein …

Homology modeling plays a central role in determining protein structure in the structural
genomics project. The importance of homology modeling has been steadily increasing …

The identification of MHC class II restricted peptide epitopes is an important goal in
immunological research. A number of computational tools have been developed for this …

For the past ten years, CASP (Critical Assessment of Structure Prediction) has monitored the
state of the art in modeling protein structure from sequence. During this period, there has …

It has long been recognized that knowledge of the 3D structures of proteins has the potential
to accelerate drug discovery, but recent developments in genome sequencing, robotics and …

Background An increasing number of researchers have released novel RNA structure
analysis and prediction algorithms for comparative approaches to structure prediction. Yet …

Thermostabilizing an enzyme while maintaining its activity for industrial or biomedical
applications can be difficult with traditional selection methods. We describe a rapid …

The current status of docking procedures for predicting protein–protein interactions starting
from their three‐dimensional (3D) structure is reassessed by evaluating blind predictions …

In this study, we investigate the extent to which techniques for homology modeling that were
developed for water-soluble proteins are appropriate for membrane proteins as well. To this …

Impressive progress in genome sequencing, protein expression and high-throughput
crystallography and NMR has radically transformed the opportunities to use protein three …