The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

For decades, lactic acid has been considered a dead-end product of glycolysis. Research in
the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor …

Diverse mechanisms for pH sensing and cytoplasmic pH homeostasis enable most bacteria
to tolerate or grow at external pH values that are outside the cytoplasmic pH range they must …

Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

We have designed programmable DNA-based nanoswitches whose closing/opening can be
triggered over specific different pH windows. These nanoswitches form an intramolecular …

Abstract Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active
transporter present on the plasma membrane of most mammalian cells and plays critical …

Abstract The Na+/H+ exchanger SLC9B2, also known as NHA2, correlates with the long-
sought-after Na+/Li+ exchanger linked to the pathogenesis of diabetes mellitus and …

The transmembrane sodium gradient is essential for both excitability of the cardiac cell and
the regulation of the cytoplasmic concentrations of Ca and protons. In addition, movements …

The deliberate production of reactive oxygen species (ROS) by phagocyte NADPH oxidase
is widely appreciated as a critical component of antimicrobial host defense. Recently …

Abstract Na+/H+ exchangers (NHEs) are ancient membrane‐bound nanomachines that
work to regulate intracellular pH, sodium levels and cell volume. NHE activities contribute to …