Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides
crucial signaling metabolites for the physiological of hosts. In healthy state, gut microbiota …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Abstract Diurnal (ie., 24-hour) oscillations of the gut microbiome have been described in
various species including mice and humans. However, the driving force behind these …

Evidence from human cohorts indicates that chronic insomnia is associated with higher risk
of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here …

The intestinal vasculature has been studied for the last 100 years, and its essential role in
absorbing and distributing ingested nutrients is well known. Recently, fascinating new …

Diet is a major determinant of the gastrointestinal microbiome composition and function, yet
our understanding of how it impacts the efficacy of prebiotics and probiotics is limited. Here …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

Interactions between the mammalian host and commensal microbiota are enforced through
a range of immune responses that confer metabolic benefits and promote tissue health and …

All species have a physiological need for sleep, and sleep is crucial for the preservation and
restoration of many physiological processes in the body. Recent research on the effects of …

A wide variety of liver functions are regulated daily by the liver circadian clock and via
systemic circadian control by other organs and cells within the gastrointestinal tract as well …