In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …

Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of
which can be reprogrammed. These processes interact with each other to adapt to the …

Intrinsic or acquired resistance to chemical drugs severely limits their therapeutic efficacy in
cancer treatment. Various intracellular antioxidant molecules, particularly glutathione (GSH) …

Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis.
Recent studies have revealed mechanisms regulating methionine metabolism within the …

While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells,
little is known of the metabolic alterations within these cells that fuel invasion. We integrated …

Tumors reprogram their metabolism to generate complex neoplastic ecosystems. Here, we
demonstrate that glioblastoma (GBM) stem cells (GSCs) display elevated activity of the …

Excitotoxicity is a prevalent pathological event in neurodegenerative diseases. The
involvement of ferroptosis in the pathogenesis of excitotoxicity remains elusive …