Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Abstract ChEMBL (https://www. ebi. ac. uk/chembl/) is a manually curated, high-quality, large-
scale, open, FAIR and Global Core Biodata Resource of bioactive molecules with drug-like …

Precision medicine provides patients with access to personally tailored treatments based on
individual-level data. However, develo** personalized therapies requires analyses with …

Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide
association studies that elucidate genetic etiology of complex traits. However, individuals …

Heart failure with preserved ejection fraction (HFpEF) is a major, worldwide health-care
problem. Few therapies for HFpEF exist because the pathophysiology of this condition is …

Objectives To explore how the blood plasma proteome fluctuates across the 24-hour day
and identify a subset of proteins that show endogenous circadian rhythmicity. Methods …

Background: The therapeutic options for IgA nephropathy are rapidly evolving, but early
diagnosis and targeted treatment remain challenging. We aimed to identify circulating …

Background Stroke is a leading cause of death worldwide, with a lack of effective treatments
for improving the prognosis. The aim of the present study was to identify novel therapeutic …

Given expanding studies in epidemiology and disease-oriented human studies offering
hundreds of associations between the human" ome" and disease, prioritizing molecules …

Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease with scarce
therapeutic alternatives, which imposes a significant economic burden on society. The …