The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …

Introduction Cancer affects an increasing number of patients each year with an
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …

Diabetes is a group of metabolic diseases characterised by chronic hyperglycaemia caused
by multiple causes, which is caused by insulin secretion and/or utilisation defects. It is …

Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases
(CAs, EC 4.2. 1.1) but they were not yet investigated for the inhibition of bacterial α-CAs …

Isocoumarins, isomeric to comarins which act as effective carbonic anhydrase (CA, EC 4.2.
1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3 …

In this study, sixty novel coumarin-monoterpene compounds were synthesized in two series
[thirty-two compounds (12–43) bearing a triazole ring in the first series, and twenty-eight …

Human carbonic anhydrase (hCA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
solid hypoxic tumors, and they are considered as prognostic tools and therapeutic targets for …

This study introduces a novel multitargeting strategy that combines carbonic anhydrase (CA)
activators and cholinesterase (ChE) inhibitors to enhance cognitive functions. A series of …

Coumarins were discovered to act as inhibitors of α-carbonic anhydrases (CAs, EC 4.2. 1.1)
after undergoing hydrolysis mediated by the esterase activity of the enzyme to the …

Diseases caused by protozoan parasites represent a huge challenge to global health care,
due to the lack of selective and efficient treatments for the management and spreading of …