Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health.
Failure to control potassium balance results in disease, including cardiac arrythmias and …

Cardiovascular diseases remain the major cause of death in the Western world. 1 Stem and
progenitor cell (SPC)–based therapies in animal models and human trials in recent years …

Millions afflicted with Chagas disease and other disorders of aberrant glycosylation suffer
symptoms consistent with altered electrical signaling such as arrhythmias, decreased …

The field of cardiac tissue engineering has developed rapidly, but structural and functional
immaturity of engineered heart tissues hinder their widespread use. Here, we show that a …

BACKGROUND: During the neonatal stage, the cardiomyocyte undergoes a constellation of
molecular, cytoarchitectural, and functional changes known collectively as cardiomyocyte …

Inward rectifier currents based on KIR2. x subunits are regarded as essential components
for establishing a stable and negative resting membrane potential in many excitable cell …

Alteration in the L-type current density is one aspect of the electrical remodeling observed in
patients suffering from cardiac arrhythmias. Changes in channel function could result from …

Therapies for heart disease are based largely on our understanding of the adult
myocardium. The dramatic differences in action potential (AP) shape between neonatal and …

Background—Pregnancy is associated with a faster heart rate (HR), which is a risk factor for
arrhythmias. However, the underlying mechanisms for this increased HR are poorly …