The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

Mass spectrometry–based quantitative proteomics is a powerful tool for gaining insights into
function and dynamics of biological systems. However, peptides with different sequences …

Extracellular vesicles (EVs) are microvesicles secreted from various cell types. We aimed to
discover a new biomarker for high Gleason score (GS) prostate cancer (PCa) in urinary EVs …

Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that
this involves activation of signal transducer and activator of transcription 1 (STAT1) and …

Integral membrane proteins (IMPs) are coded by 20–30% of human genes and execute
important functions–transmembrane transport, signal transduction, cell-cell communication …

Proteomic analysis of urinary extracellular vesicles (EVs) is a powerful approach to discover
potential bladder cancer (BCa) biomarkers, however urine contains numerous EVs derived …

Neutrophils are found to be infiltrated in tumour tissues of patients with colitis-associated
cancer (CAC) and colorectal cancer (CRC), and CD177 is mainly expressed in neutrophils …

The fact that cancer is a leading cause of death all around the world has naturally sparked
major efforts in the pursuit of novel and more efficient biomarkers that could better serve as …

At the moment, there is no sensitive clinical test for detecting early-stage colorectal cancer
(CRC). Target proteomics has enabled high-throughput verification of hundreds of …