Male erectile dysfunction (ED) refers to incompetency to reaching and retaining adequate
penile tumescence for sexual intercourse. Over 152 million men globally suffer from ED and …

Endogenous opioids, first described more than 40 years ago, have long been recognized for
their main role as important neuromodulators within the central nervous system. More …

Introduction Substance abuse has become a worldwide health problem, leading to
numerous consequences such as social problems among family members, abnormal …

Background Hypersexual and hyposexual behaviors are common concomitant of substance
use disorders (SUD). On the one hand, the regular consumption of alcohol or illegal drugs …

Background Opioid analgesics have been widely used to relieve chronic pain conditions;
however, a connection between opioid analgesic administration and increased susceptibility …

Sex is a key function of human beings. Its physical, emotional, psychological, and social
aspects permeate into many parts of our lives. Therefore, it is a major contributor to “Quality …

Background While methadone maintenance therapy (MMT) in patients with opioid use
disorder (OUD) decreases the risk of substance use relapses and criminal and risky sexual …

Background and Objectives Compliance and maintenance of abstinence is a major issue in
substance use disorders. Adverse effects of opioid maintenance treatments (OMT) include …

Background Some patients with opioid use disorder (OUD) are treated with methadone
maintenance therapy (MMT). However, as with opioids, methadone has major side-effects; …

Objectives: To review the currently available evidence on transfer strategies from
methadone to sublingual buprenorphine used in clinical trials and observational studies of …