Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment
Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has
a proven safety record when appropriately applied to eliminate weeds. However, over the …
a proven safety record when appropriately applied to eliminate weeds. However, over the …
Medical management of paraquat ingestion
Poisoning by paraquat herbicide is a major medical problem in parts of Asia while sporadic
cases occur elsewhere. The very high case fatality of paraquat is due to inherent toxicity and …
cases occur elsewhere. The very high case fatality of paraquat is due to inherent toxicity and …
Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy
Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …
Cellular models and in vitro assays for the screening of modulators of P-gp, MRP1 and BCRP
M Gameiro, R Silva, C Rocha-Pereira, H Carmo… - Molecules, 2017 - mdpi.com
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
Inhaled chemotherapy in lung cancer: future concept of nanomedicine
P Zarogoulidis, E Chatzaki, K Porpodis… - International journal …, 2012 - Taylor & Francis
Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new
methods of drug delivery and pharmaceuticals have been investigated in vitro, and in …
methods of drug delivery and pharmaceuticals have been investigated in vitro, and in …
Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic
Recently, chemotherapy has been one of the most important therapeutic approaches for
malignant tumors. The tumor tissular or intracellular microenvironment-sensitive polymer …
malignant tumors. The tumor tissular or intracellular microenvironment-sensitive polymer …
Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat‐induced liver injury in rats: Modulation of oxidative stress and Nrf2 pathway
Paraquat (PQ) is a widely used herbicide all over the world, which is highly toxic for animals
and humans. Its cytotoxicity is based on reactive radical generation. The aim of this study is …
and humans. Its cytotoxicity is based on reactive radical generation. The aim of this study is …
Drug transporters in the lung—do they play a role in the biopharmaceutics of inhaled drugs?
C Bosquillon - Journal of pharmaceutical sciences, 2010 - Elsevier
The role of transporters in drug absorption, distribution and elimination processes as well as
in drug–drug interactions is increasingly being recognised. Although the lungs express high …
in drug–drug interactions is increasingly being recognised. Although the lungs express high …
Clinical features and prognosis of paraquat poisoning in French Guiana: a review of 62 cases
N Elenga, C Merlin, R Le Guern, R Kom-Tchameni… - Medicine, 2018 - journals.lww.com
Paraquat is a nonselective contact herbicide of great toxicological importance, being
associated with high mortality rates. Because of its high toxicity, the European Union …
associated with high mortality rates. Because of its high toxicity, the European Union …
A user-friendly herbicide derived from photo-responsive supramolecular vesicles
Paraquat, as one of the most widely used herbicides globally, is highly toxic to humans, and
chronic exposure and acute ingestion leads to high morbidity and mortality rates. Here, we …
chronic exposure and acute ingestion leads to high morbidity and mortality rates. Here, we …