Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

With the rapid advance of single-cell sequencing technology, cell heterogeneity in various
biological processes was dissected at different omics levels. However, single-cell mono …

Cutaneous T cell lymphoma (CTCL) is characterized by the accumulation of malignant T
cells in the skin. However, advanced CTCL pathophysiology remains elusive and …

Staphylococcus aureus is suspected to fuel disease activity in cutaneous T-cell lymphomas.
In this study, we investigate the effect of a recombinant, antibacterial protein, endolysin (XZ …

Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma
(CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to …

Purpose: Clonal malignant T lymphocytes constitute only a fraction of T cells in mycosis
fungoides skin tumors and in the leukemic blood of Sézary syndrome, the classic types of …

The human skin is populated by a diverse pool of memory T cells, which can act rapidly in
response to pathogens and cancer antigens. Tissue‐resident memory T cells (TRM) have …

Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common
cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the …

Cutaneous T-cell lymphoma (CTCL) is a rare cancer of skin-homing T cells. A subgroup of
patients develops large cell transformation with rapid progression to an aggressive …

Background: Single-cell sequencing (SCS) is a technique used to analyze the genome,
transcriptome, epigenome, and other genetic data at the level of a single cell. The procedure …