CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its
essential role in physiological activities in normal cells and pathological activities in cancer …

Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver
Disease (NAFLD), the main cause of chronic liver complications. The development of NASH …

Non-alcoholic fatty liver disease (NAFLD) with its more progressive form non-alcoholic
steatohepatitis (NASH) has become the most common chronic liver disease, thereby …

The cell-surface glycoprotein CD44 is involved in a multitude of important physiological
functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte …

Mesenchymal stem cells (MSC) have become a promising tool for therapeutic intervention.
Their unique features, including self-renewal, multipotency and immunomodulatory …

The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling
as a result of injury and repair. Over the past decade, mounting evidence in humans and …

Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To
identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for …

The frequency of prediabetes is increasing as the prevalence of obesity rises worldwide. In
prediabetes, hyperglycemia, insulin resistance, and inflammation and metabolic …

Obesity, type 2 diabetes mellitus (T2 DM) and aging are associated with pancreatic cancer
risk, but the mechanisms of pancreatic cancer development caused by these factors are not …

Chronic liver diseases from varying etiologies generally lead to liver fibrosis and cirrhosis.
Among them, non-alcoholic fatty liver disease (NAFLD) affects roughly one-quarter of the …