It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

The epithelial to mesenchymal transition (EMT) is a key cellular process underlying cancer
progression, with multiple intermediate states whose molecular hallmarks remain poorly …

Cancer metastasis is the main cause of cancer‐related death, and dissemination of tumor
cells through the blood circulation is an important intermediate step that also exemplifies the …

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly …

Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the
presence of extra centrosomes,,,. However, a direct mechanistic link between extra …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Eggs and sperm develop through a specialized cell division called meiosis. During meiosis,
the number of chromosomes is reduced by two sequential divisions in preparation for …

The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell
death that occurs during mitosis. Here, we propose that mitotic catastrophe results from a …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …