Resective epilepsy surgery for drug-resistant focal epilepsy: a review

BC Jobst, GD Cascino - Jama, 2015 - jamanetwork.com
Importance Epilepsy surgery is indicated for patients with focal seizures who do not respond
to appropriate antiepileptic drug therapy consisting of 2 or more medications. Objectives To …

Systematic review and network meta-analysis of resective surgery for mesial temporal lobe epilepsy

P Jain, G Tomlinson, C Snead, B Sander… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objective To evaluate the effectiveness of anterior temporal lobectomy (ATL) versus
selective amygdalohippocampectomy (SAH) on seizure-free outcome in patients with …

The long-term outcomes of epilepsy surgery

M Mohan, S Keller, A Nicolson, S Biswas, D Smith… - PloS one, 2018 - journals.plos.org
Objective Despite modern anti-epileptic drug treatment, approximately 30% of epilepsies
remain medically refractory and for these patients, epilepsy surgery may be a treatment …

Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy

SS Keller, GR Glenn, B Weber, BAK Kreilkamp… - Brain, 2017 - academic.oup.com
Approximately one in every two patients with pharmacoresistant temporal lobe epilepsy will
not be rendered completely seizure-free after temporal lobe surgery. The reasons for this are …

Predicting surgery targets in temporal lobe epilepsy through structural connectome based simulations

F Hutchings, CE Han, SS Keller, B Weber… - PLoS computational …, 2015 - journals.plos.org
Temporal lobe epilepsy (TLE) is a prevalent neurological disorder resulting in disruptive
seizures. In the case of drug resistant epilepsy resective surgery is often considered. This is …

Surgical treatment for mesial temporal lobe epilepsy associated with hippocampal sclerosis

B Mathon, LB Ulvin, C Adam, M Baulac, S Dupont… - Revue …, 2015 - Elsevier
Introduction Hippocampal sclerosis is the most common cause of pharmacoresistant
epilepsy amenable for surgical treatment and seizure control. The aim of this article is to …

Factors affecting seizure outcome after epilepsy surgery: an observational series

GS Bell, J De Tisi, JC Gonzalez-Fraile… - Journal of Neurology …, 2017 - jnnp.bmj.com
Importance Surgical treatment can bring seizure remission in people with focal epilepsy but
requires careful selection of candidates. Objectives To determine which preoperative factors …

Brain expression of inflammatory mediators in mesial temporal lobe epilepsy patients

B Leal, J Chaves, C Carvalho, R Rangel… - Journal of …, 2017 - Elsevier
Neuroinflammation may be central in epileptogenesis. In this study we analysed
inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with …

Toll‐like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE‐induced epilepsy in mice

A Gross, F Benninger, R Madar, T Illouz, K Griffioen… - …, 2017 - Wiley Online Library
Objective Epilepsy affects 60 million people worldwide. Despite the development of
antiepileptic drugs, up to 35% of patients are drug refractory with uncontrollable seizures …

Epilepsy surgery in low-and middle-income countries: A sco** review

MM Watila, F **ao, MR Keezer, A Miserocchi… - Epilepsy & Behavior, 2019 - Elsevier
Background Epilepsy surgery is an important treatment option for people with drug-resistant
epilepsy. Surgical procedures for epilepsy are underutilized worldwide, but it is far worse in …