The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

Extracellular vesicles (EVs) are released from all cells in the body, forming an important
intercellular communication network that contributes to health and disease. The contents of …

Extracellular vesicles (EVs) are a means of cell-to-cell communication and can facilitate the
exchange of a broad array of molecules between adjacent or distant cells. Platelets are …

Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …

It is clear from Part I of this series that extracellular vesicles (EVs) play a critical role in
maintaining the homeostasis of most, if not all, normal physiological systems. However, the …

Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into
their environment. Why do cells release vesicles? Initial studies showed that eukaryotic …

Extracellular vesicles, such as exosomes and microvesicles, are host cell-derived packages
of information that allow cell–cell communication and enable cells to rid themselves of …

Platelet activation leads to secretion of granule contents and to the formation of
microvesicles by shedding of membranes from the cell surface. Recently, we have described …

Our failure to produce truly non-thrombogenic materials may reflect a failure to fully
understand the mechanisms of biomaterial-associated thrombosis. The community has …