Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-
derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its …

Highlights•Neurotrophins have been linked to several disorders, including AD and
depression.•Complex biology has led to difficulties in identifying suitable drug …

Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …

The Trk family of receptors play a wide variety of roles in physiological and disease
processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in …

Brain‐derived neurotrophic factor (BDNF) is the most studied neurotrophin involved in
synaptic plasticity processes that are required for long‐term learning and memory …

The growth factor brain-derived neurotrophic factor (BDNF), and its receptor tropomyosin-
related kinase receptor type B (TrkB) play an active role in numerous areas of the adult …

Brain-derived neurotrophic factor (BDNF) and its single transmembrane receptor,
tropomysin-related kinase B (TrkB), are essential for adult synaptic plasticity and the …

Peripheral nerve injury disrupts the normal functions of sensory and motor neurons by
damaging the integrity of axons and Schwann cells. In contrast to the central nervous …