Advances in mass spectrometry-based clinical biomarker discovery

CA Crutchfield, SN Thomas, LJ Sokoll, DW Chan - Clinical proteomics, 2016 - Springer
The greatest unmet needs in biomarker discovery are those discoveries that lead to the
development of clinical diagnostic tests. These clinical diagnostic tests can provide early …

Emerging biomarkers in the diagnosis of prostate cancer

X Filella, E Fernandez-Galan… - Pharmacogenomics …, 2018 - Taylor & Francis
Prostate cancer (PCa) is the second most common cancer in men worldwide. A large
proportion of PCa are latent, never destined to progress or affect the patients' life. It is of …

Glycosylation‐based serum biomarkers for cancer diagnostics and prognostics

A Kirwan, M Utratna, ME O'Dwyer… - BioMed research …, 2015 - Wiley Online Library
Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …

Improvement of prostate cancer diagnosis by detecting PSA glycosylation-specific changes

E Llop, M Ferrer-Batallé, S Barrabés… - …, 2016 - pmc.ncbi.nlm.nih.gov
New markers based on PSA isoforms have recently been developed to improve prostate
cancer (PCa) diagnosis. However, novel approaches are still required to differentiate …

Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis

L Cao, TM Lih, Y Hu, M Schnaubelt, SY Chen… - Nature …, 2022 - nature.com
Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins
in physiological and pathological processes. However, quantitative characterization of core …

Mass spectrometry-based analysis of serum N-glycosylation changes in patients with Parkinson's disease

M Xu, H **, Z Wu, Y Han, J Chen, C Mao… - ACS chemical …, 2022 - ACS Publications
It is urgently needed to find reliable biofluid biomarkers for early diagnosis of Parkinson's
disease in order to achieve better treatment. Promising biomarkers can be found in …

Integrated proteomic and glycoproteomic analyses of prostate cancer cells reveal glycoprotein alteration in protein abundance and glycosylation

P Shah, X Wang, W Yang, ST Eshghi, S Sun… - Molecular & Cellular …, 2015 - mcponline.org
Prostate cancer is the most common cancer among men in the US and worldwide, and
androgen-deprivation therapy remains the principal treatment for patients. Although a …

Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live Cells

Q Zhu, JL Chaubard, D Geng, J Shen… - Journal of the …, 2024 - ACS Publications
Core fucosylation, the attachment of an α-1, 6-linked-fucose to the N-glycan core
pentasaccharide, is an abundant protein modification that plays critical roles in various …

Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer

J Tkac, V Gajdosova, S Hroncekova… - Journal of the …, 2019 - royalsocietypublishing.org
The initial part of this review details the controversy behind the use of a serological level of
prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel …

Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology

E Fernandes, J Sores, S Cotton, A Peixoto… - …, 2020 - pmc.ncbi.nlm.nih.gov
Esophageal (OC), gastric (GC) and colorectal (CRC) cancers are amongst the digestive
track tumors with higher incidence and mortality due to significant molecular heterogeneity …