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Advances in mass spectrometry-based clinical biomarker discovery
The greatest unmet needs in biomarker discovery are those discoveries that lead to the
development of clinical diagnostic tests. These clinical diagnostic tests can provide early …
development of clinical diagnostic tests. These clinical diagnostic tests can provide early …
Emerging biomarkers in the diagnosis of prostate cancer
X Filella, E Fernandez-Galan… - Pharmacogenomics …, 2018 - Taylor & Francis
Prostate cancer (PCa) is the second most common cancer in men worldwide. A large
proportion of PCa are latent, never destined to progress or affect the patients' life. It is of …
proportion of PCa are latent, never destined to progress or affect the patients' life. It is of …
Glycosylation‐based serum biomarkers for cancer diagnostics and prognostics
Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …
Improvement of prostate cancer diagnosis by detecting PSA glycosylation-specific changes
E Llop, M Ferrer-Batallé, S Barrabés… - …, 2016 - pmc.ncbi.nlm.nih.gov
New markers based on PSA isoforms have recently been developed to improve prostate
cancer (PCa) diagnosis. However, novel approaches are still required to differentiate …
cancer (PCa) diagnosis. However, novel approaches are still required to differentiate …
Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis
Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins
in physiological and pathological processes. However, quantitative characterization of core …
in physiological and pathological processes. However, quantitative characterization of core …
Mass spectrometry-based analysis of serum N-glycosylation changes in patients with Parkinson's disease
M Xu, H **, Z Wu, Y Han, J Chen, C Mao… - ACS chemical …, 2022 - ACS Publications
It is urgently needed to find reliable biofluid biomarkers for early diagnosis of Parkinson's
disease in order to achieve better treatment. Promising biomarkers can be found in …
disease in order to achieve better treatment. Promising biomarkers can be found in …
Integrated proteomic and glycoproteomic analyses of prostate cancer cells reveal glycoprotein alteration in protein abundance and glycosylation
Prostate cancer is the most common cancer among men in the US and worldwide, and
androgen-deprivation therapy remains the principal treatment for patients. Although a …
androgen-deprivation therapy remains the principal treatment for patients. Although a …
Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live Cells
Q Zhu, JL Chaubard, D Geng, J Shen… - Journal of the …, 2024 - ACS Publications
Core fucosylation, the attachment of an α-1, 6-linked-fucose to the N-glycan core
pentasaccharide, is an abundant protein modification that plays critical roles in various …
pentasaccharide, is an abundant protein modification that plays critical roles in various …
Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer
J Tkac, V Gajdosova, S Hroncekova… - Journal of the …, 2019 - royalsocietypublishing.org
The initial part of this review details the controversy behind the use of a serological level of
prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel …
prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel …
Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology
Esophageal (OC), gastric (GC) and colorectal (CRC) cancers are amongst the digestive
track tumors with higher incidence and mortality due to significant molecular heterogeneity …
track tumors with higher incidence and mortality due to significant molecular heterogeneity …