Microbial and animal rhodopsins: structures, functions, and molecular mechanisms
Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …
Photoreceptor cells and RPE contribute to the development of diabetic retinopathy
D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …
vascular disease, but work in the past years has shown abnormalities also in the neural …
An expanding role for nonvisual opsins in extraocular light sensing physiology
We live on a planet that is bathed in daily and seasonal sunlight cycles. In this context,
terrestrial life forms have evolved mechanisms that directly harness light energy (plants) or …
terrestrial life forms have evolved mechanisms that directly harness light energy (plants) or …
Crystal structure of a lipid G protein–coupled receptor
The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking,
endothelial development and integrity, heart rate, and vascular tone and maturation by …
endothelial development and integrity, heart rate, and vascular tone and maturation by …
Mammalian G proteins and their cell type specific functions
Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …
Chemistry of the retinoid (visual) cycle
As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …
G protein–coupled receptor rhodopsin
K Palczewski - Annu. Rev. Biochem., 2006 - annualreviews.org
The rhodopsin crystal structure provides a structural basis for understanding the function of
this and other G protein–coupled receptors (GPCRs). The major structural motifs observed …
this and other G protein–coupled receptors (GPCRs). The major structural motifs observed …
Crystal structure of the ligand-free G-protein-coupled receptor opsin
JH Park, P Scheerer, KP Hofmann, HW Choe, OP Ernst - Nature, 2008 - nature.com
In the G-protein-coupled receptor (GPCR) rhodopsin, the inactivating ligand 11-cis-retinal is
bound in the seven-transmembrane helix (TM) bundle and is cis/trans isomerized by light to …
bound in the seven-transmembrane helix (TM) bundle and is cis/trans isomerized by light to …
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis …
K Kristiansen - Pharmacology & therapeutics, 2004 - Elsevier
The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …
[HTML][HTML] Chemistry and biology of vision
K Palczewski - Journal of Biological Chemistry, 2012 - Elsevier
Visual perception in humans occurs through absorption of electromagnetic radiation from
400 to 780 nm by photoreceptors in the retina. A photon of visible light carries a sufficient …
400 to 780 nm by photoreceptors in the retina. A photon of visible light carries a sufficient …