The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

Rab5 and rab7 proteins belong to a superfamily of small molecular weight GTPases known
to be associated with early and late endosomes, respectively. The rab5 protein plays an …

In the history of science and technology, researchers have always undertaken endeavors to
enhance the degree of “directness of measurement”. With “directness of measurement”, we …

Rab11 is a small GTP-binding protein that in cultured mammalian cells has been shown to
be concentrated in the pericentriolar endosomal recycling compartment and to play a key …

Salmonella enterica requires a type III secretion system, designated Spi/Ssa, to survive and
proliferate within macrophages. The Spi/Ssa system is encoded within the SPI‐2 …

Hepatitis C virus (HCV) is a major human pathogen associated with life-threatening liver
disease. Entry into hepatocytes requires CD81 and a putative second receptor. In this study …

The growth-associated protein B-50 (GAP-43) is a presynaptic protein. Its expression is
largely restricted to the nervous system. B-50 is frequently used as a marker for sprouting …

We have shown previously that the ADP-ribosylation factor (ARF)-6 GTPase localizes to the
plasma membrane and intracellular endosomal compartments. Expression of ARF6 mutants …

The intracellular human pathogens Legionella pneumophila and Mycobacterium
tuberculosis reside in altered phagosomes that do not fuse with lysosomes and are only …