Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

The regulative capability of single cells to give rise to all primary embryonic lineages is
termed pluripotency. Observations of fluctuating gene expression and phenotypic …

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may …

Cellular differentiation and lineage commitment are considered to be robust and irreversible
processes during development. Recent work has shown that mouse and human fibroblasts …

Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …

Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …

Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell
types of an adult organism. This property can be captured indefinitely through derivation of …

The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo
remains controversial. We present transcriptional and functional data to identify the …

The applications of modern artificial intelligence (AI) algorithms within the field of aging
research offer tremendous opportunities. Aging is an almost universal unifying feature …

Abstract NAT10-catalyzed N4-acetylcytidine (ac4C) has emerged as a vital post-
transcriptional modulator on the coding transcriptome by promoting mRNA stability …