Extrahepatic morbidity and mortality of chronic hepatitis C

F Negro, D Forton, A Craxì, MS Sulkowski, JJ Feld… - Gastroenterology, 2015 - Elsevier
Chronic hepatitis C virus (HCV) infection is associated with several extrahepatic
manifestations. Patients with HCV may develop mixed cryoglobulinemia and its sequelae …

HCV extrahepatic manifestations

L Kuna, J Jakab, R Smolic, GY Wu… - Journal of Clinical and …, 2019 - pmc.ncbi.nlm.nih.gov
Hepatitis C virus (HCV) has been shown to affect many tissues other than liver. However, of
the many extrahepatic manifestations (EMs) that have been associated with HCV, including …

Inhibiting PCSK9—biology beyond LDL control

RM Stoekenbroek, G Lambert, B Cariou… - Nature Reviews …, 2019 - nature.com
Clinical trials have unequivocally shown that inhibition of proprotein convertase
subtilisin/kexin type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by …

[HTML][HTML] 2020 Taiwan consensus statement on the management of hepatitis C: part (I) general population

ML Yu, PJ Chen, CY Dai, TH Hu, CF Huang… - Journal of the Formosan …, 2020 - Elsevier
Hepatitis C virus (HCV) infection remains a major public health issue with high prevalence in
Taiwan. Recently, the advent of direct-acting antiviral (DAA) agents, with higher efficacy …

[HTML][HTML] Hepatitis C virus, cholesterol and lipoproteins—impact for the viral life cycle and pathogenesis of liver disease

DJ Felmlee, ML Hafirassou, M Lefevre, TF Baumert… - Viruses, 2013 - mdpi.com
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic
hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates …

Hepatitis C infection and clearance: impact on atherosclerosis and cardiometabolic risk factors

A Mostafa, MK Mohamed, M Saeed, A Hasan… - Gut, 2010 - gut.bmj.com
Background Chronic hepatitis C (HCV) infection is associated with diabetes and favourable
lipids. Objective To study the effect of this paradox on atherosclerosis and cardiometabolic …

Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy

PC Tsai, CF Huang, ML Yeh, MH Hsieh… - Clinical and …, 2024 - pmc.ncbi.nlm.nih.gov
Background/Aims Chronic hepatitis C (CHC) patients who failed antiviral therapy are at
increased risk for hepatocellular carcinoma (HCC). This study assessed the potential role of …

PCSK9 impedes hepatitis C virus infectionin vitroand modulates liver CD81 expression

P Labonté, S Begley, C Guévin, MC Asselin… - Hepatology, 2009 - journals.lww.com
Human PCSK9 is known to enhance the degradation of membrane-bound receptors such as
the hepatocyte low-density lipoprotein receptor (LDLR), ApoER2, and very low-density …

Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease …

E Cassol, V Misra, A Holman, A Kamat… - BMC infectious …, 2013 - Springer
Background Metabolic abnormalities are common in HIV-infected individuals on
antiretroviral therapy (ART), but the biochemical details and underlying mechanisms of …

Gene expression profiling indicates the roles of host oxidative stress, apoptosis, lipid metabolism, and intracellular transport genes in the replication of hepatitis C virus

S Blackham, A Baillie, F Al-Hababi… - Journal of …, 2010 - journals.asm.org
Hepatitis C virus (HCV) is a leading cause of chronic liver disease. The identification and
characterization of key host cellular factors that play a role in the HCV replication cycle are …