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[HTML][HTML] Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: a step forward in the discovery of neuroprotective agents
P Linciano, C Sorbi, G Rossino, D Rossi… - European journal of …, 2023 - Elsevier
Abstract Sigma-1 receptor (S1R) has been considered a promising therapeutic target for
several neurodegenerative diseases and S1R agonists have shown neuroprotective activity …
several neurodegenerative diseases and S1R agonists have shown neuroprotective activity …
Inhibition Kinetics and Theoretical Studies on Zanthoxylum chalybeum Engl. Dual Inhibitors of α-Glucosidase and α-Amylase
Compounds from Zanthoxylum chalybeum Engl. were previously reported for inhibitory
activities of amylase and glucosidase enzymatic action on starch as a preliminary study …
activities of amylase and glucosidase enzymatic action on starch as a preliminary study …
Discovery of RC-752, a novel sigma-1 receptor antagonist with antinociceptive activity: a promising tool for fighting neuropathic pain
Neuropathic pain (NP) is a chronic condition resulting from damaged pain-signaling
pathways. It is a debilitating disorder that affects up to 10% of the world's population …
pathways. It is a debilitating disorder that affects up to 10% of the world's population …
An in silico molecular docking and simulation study to identify potential anticancer phytochemicals targeting the RAS signaling pathway
The dysregulation of the rat sarcoma (RAS) signaling pathway, particularly the MAPK/ERK
cascade, is a hallmark of many cancers, leading to uncontrolled cellular proliferation and …
cascade, is a hallmark of many cancers, leading to uncontrolled cellular proliferation and …
[HTML][HTML] Novel high affinity sigma-1 receptor ligands from minimal ensemble docking-based virtual screening
Sigma-1 receptor (S1R) is an intracellular, multi-functional, ligand operated protein that also
acts as a chaperone. It is considered as a pluripotent drug target in several pathologies. The …
acts as a chaperone. It is considered as a pluripotent drug target in several pathologies. The …
[HTML][HTML] Insight of Natural Compounds Halimane Diterpenoids against Mycobacterium tuberculosis: Virtual Screening, DFT, Drug-Likeness, and Molecular Dynamics …
LGE Andiga, BD Bekono, M Bikele, PP Ongué… - Computational …, 2024 - scirp.org
In the purpose to design novel antituberculosis (anti-TB) drugs agents against
Mycobacterium tuberculosis (Mtb), we have built a molecular library around 42 Halimane …
Mycobacterium tuberculosis (Mtb), we have built a molecular library around 42 Halimane …
Use of Psychotropics in COVID-19: Another Anti-inflammatory Pathway
J Morillo, V Morillo, MA Marquina… - Current Psychiatry …, 2023 - benthamdirect.com
The emergence of the novel coronavirus SARS-CoV-2 has significantly impacted the world's
population, disrupting healthcare systems around the globe and leading to human and …
population, disrupting healthcare systems around the globe and leading to human and …
[HTML][HTML] Sigma receptor and aquaporin modulators: chiral resolution, configurational assignment, and preliminary biological profile of RC752 enantiomers
The key role of chiral small molecules in drug discovery programs has been deeply
investigated throughout last decades. In this context, our previous studies highlighted the …
investigated throughout last decades. In this context, our previous studies highlighted the …