Silent synapses abound in the young brain, representing an early step in the pathway of
experience-dependent synaptic development. Discovered amidst the debate over whether …

Alzheimer's disease (AD) is an age-related dementia and neurodegenerative disorder,
characterized by Aβ and tau protein deposition impairing learning, memory and suppressing …

Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by
perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in …

INTRODUCTION N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated, calcium-
permeable neurotransmitter receptors. They are fundamental to brain development, they …

Traditionally, glutamate transporters have been viewed as membrane proteins that harness
the electrochemical gradient to slowly transport glutamate from the extracellular space into …

The emergence of astroglia as an important participant of the synaptic machinery has led to
the 'tripartite synapse'hypothesis. Recent findings suggest that synaptic signaling also …

Genetically encoded sensors of glutamate concentration are based on FRET between cyan
and yellow fluorescent proteins bracketing a bacterial glutamate-binding protein. Such …

Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …

The corticostriatal pathway provides most of the excitatory glutamatergic input into the
striatum and it plays an important role in the development of the phenotype of Huntington's …

Background The formation and retrieval of fear memories depends on orchestrated synaptic
activity of neuronal ensembles within the hippocampus, and it is becoming increasingly …