Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …

Background: The spontaneously hypertensive rat (SHR) is extensively used to study
hypertension. Gut microbiota dysbiosis is a notable feature in SHR for reasons unknown …

Multiple GWAS studies have reported strong association of cardiac QT-interval to a region
on HSA17. Interestingly, a rat locus homologous to this region is also linked to QT-intervals …

Abstract Purpose of Review The study aims to capture the history and lineage of
hypertension researchers from the University of Toledo in Ohio and showcase their …

Hypertension is a classic example of a complex polygenic trait, impacted by quantitative trait
loci (QTL) containing candidate genes thought to be responsible for blood pressure (BP) …

Chromosomal substitution strategies provide a powerful tool to anonymously reveal the
relationship between DNA sequence variants and a normal or disease phenotype of …

Advances in molecular genetics have provided well‐defined physical genetic maps and
large numbers of genetic markers for both model organisms and humans. It is now possible …

Figure. A, DNA sequencing results from the polymerase chain reaction products for both
secreted phosphoprotein 2 (Spp2) nonfounder (NF) and knock-in (KI) at the location Chr9 …

Abstract Metabolic Syndrome (MetS) is a collection of diseases including obesity,
hypertension, high cholesterol, and other related disorders that affects more quarter of the …

Hypertension is a classic example of a complex polygenic trait, impacted by quantitative trait
loci (QTL) containing candidate genes thought to be responsible for blood pressure (BP) …