The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal
networks, made of actin filaments, microtubules, and intermediate filaments. These three …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

The coordinated interplay of cytoskeletal networks critically determines tissue biomechanics
and structural integrity. Here, we show that plectin, a major intermediate filament-based …

Carcinoma dissemination can occur when heterogeneous tumor and tumor-stromal cell
clusters migrate together via collective migration. Cells at the front lead and direct collective …

Hemidesmosomes are specialized cell-matrix adhesion structures that are associated with
the keratin cytoskeleton. Although the adhesion function of hemidesmosomes has been …

Integrin‐based mechanotransduction involves a complex focal adhesion (FA)‐associated
machinery that is able to detect and respond to forces exerted either through components of …

Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form
the cytoskeleton, are composed of a large and diverse family of proteins. Efforts to elucidate …

The cytoskeleton is a complex network of interconnected biopolymers consisting of actin
filaments, microtubules, and intermediate filaments. These biopolymers work in concert to …

Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules,
impact cell and tissue functions in physiology and diseases. How living cells integrate …