Recent investigations in bacteria suggest that membraneless organelles play a crucial role
in the subcellular organization of bacterial cells. However, the biochemical functions and …

Proper chromosome segregation during cell division is essential in all domains of life. In the
majority of bacterial species, faithful chromosome segregation is mediated by the tripartite …

Liquid-liquid phase-separated (LLPS) states are key to compartmentalizing components in
the absence of membranes; however, it is unclear whether LLPS condensates are actively …

How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …

Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …

Bacterial cells require DNA segregation machinery to properly distribute a genome to both
daughter cells upon division. The most common system involved in chromosome and …

All cells fold their genomes, including bacterial cells, where the chromosome is compacted
into a domain-organized meshwork called the nucleoid. How compaction and domain …

Three-component ParABS systems are widely distributed factors for plasmid partitioning and
chromosome segregation in bacteria. ParB acts as adaptor protein between the 16–base …

Borrelia burgdorferi, the tick-transmitted spirochete agent of Lyme disease, has a highly
segmented genome with a linear chromosome and various linear or circular plasmids. Here …

Toxin–antitoxin (TA) systems are small selfish genetic modules that increase vertical stability
of their replicons. They have long been thought to stabilize plasmids by killing cells that fail …