Monomers and oligomers of the amyloid-β peptide aggregate to form the fibrils found in the
brains of Alzheimer's disease patients. These monomers and oligomers are largely …

Amyloid-β and α-synuclein are intrinsically disordered proteins (IDPs), which are at the
center of Alzheimer's and Parkinson's disease pathologies, respectively. These IDPs are …

Tyrosinases and catechol oxidases belong to the family of polyphenol oxidases (PPOs).
Tyrosinases catalyze the o-hydroxylation and oxidation of phenolic compounds, whereas …

The key properties and high versatility of metal nanoparticles have shed new perspectives
on cancer therapy, with copper nanoparticles gaining great interest because of the ability to …

Experiments face challenges in the analysis of intrinsically disordered proteins in solution
due to fast conformational changes and enhanced aggregation propensity. Computational …

Nature is full of examples of processes that, through evolution, have been perfected over the
ages to effectively use matter and sustain life. Here, we present our strategies for designing …

Our recent studies show that the single Tyr residue in the sequence of amyloid-β42 (Aβ42) is
reactive toward various ligands, including metals and adenosine trisphospate (see …

Alanine scanning is a tool in molecular biology that is commonly used to evaluate the
contribution of a specific amino acid residue to the stability and function of a protein …

We present a new protocol for deriving force constant parameters that are used in molecular
mechanics (MM) force fields to describe the bond‐stretching, angle‐bending, and dihedral …

The aggregation of Aβ42 peptides is considered as one of the main causes for the
development of Alzheimer's disease. In this context, Zn2+ and Cu2+ play a significant role in …