Engineering dendritic cell vaccines to improve cancer immunotherapy

CR Perez, M De Palma - Nature communications, 2019 - nature.com
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …

Innate immunity and cancer pathophysiology

L Maiorino, J Daßler-Plenker, L Sun… - Annual Review of …, 2022 - annualreviews.org
Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …

Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy

L Van De Laar, PJ Coffer… - Blood, The Journal of the …, 2012 - ashpublications.org
Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic
system, specialized in antigen capture, processing, and presentation. The different DC …

[HTML][HTML] Prognostic significance of tumor immune microenvironment and immunotherapy: novel insights and future perspectives in gastric cancer

DC Lazăr, MF Avram, I Romoșan… - World journal of …, 2018 - ncbi.nlm.nih.gov
Despite a decrease in gastric cancer incidence, the development of novel biologic agents
and combined therapeutic strategies, the prognosis of gastric cancer remains poor …

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice

E Amiel, B Everts, TC Freitas, IL King… - The Journal of …, 2012 - journals.aai.org
Dendritic cells (DCs) are potent inducers of T cell immunity, and autologous DC vaccination
holds promise for the treatment of cancers and chronic infectious diseases. In practice …

Tumor suppressors having oncogenic functions: the double agents

N Datta, S Chakraborty, M Basu, MK Ghosh - Cells, 2020 - mdpi.com
Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …

[HTML][HTML] Gastric cancer and the epoch of immunotherapy approaches

E Niccolai, A Taddei, D Prisco… - World Journal of …, 2015 - ncbi.nlm.nih.gov
The incidence of gastric cancer (GC) fell dramatically over the last 50 years, but according to
IARC-Globocan 2008, it is the third most frequent cause of cancer-related deaths with a case …

Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses

N Seyfizadeh, R Muthuswamy, DA Mitchell… - Critical reviews in …, 2016 - Elsevier
Better prognoses associated with increased T cell infiltration of tumors, as seen with
chimeric antigen receptor (CAR) T cell therapies and immune checkpoint inhibitors, portray …

PTEN function at the interface between cancer and tumor microenvironment: implications for response to immunotherapy

F Conciatori, C Bazzichetto, I Falcone… - International Journal of …, 2020 - mdpi.com
Mounting preclinical and clinical evidence indicates that rewiring the host immune system in
favor of an antitumor microenvironment achieves remarkable clinical efficacy in the …

Selenium regulation of the immune function of dendritic cells in mice through the ERK, Akt and RhoA/ROCK pathways

L Zhang, H **a, K **a, X Liu, X Zhang, J Dai… - … Trace Element Research, 2021 - Springer
Selenium levels can regulate the function of T cells, macrophages, B cells, natural killer cells
and other immune cells. However, the effect of selenium on the immune function of dendritic …