The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophan 2, 3-dioxygenase 2 (TDO2) catalyze
the commitment step of the kynurenine (KYN) metabolic pathway. Traditionally the …

Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …

Transplantation of hematopoietic stem cells (HSCs) with a naturally occurring CCR5
mutation confers a loss of detectable HIV-1 in the patient, making ablation of the CCR5 gene …

Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

Nanomaterials have the potential to improve how patients are clinically treated and
diagnosed. While there are a number of nanomaterials that can be used toward improved …