To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …

The human apolipoprotein B mRNA-editing enzyme catalytic polypeptide–like 3 (APOBEC3,
referred to as A3) proteins are cellular cytidine deaminases that potently restrict retrovirus …

Viruses manipulate host factors to enhance their replication and evade cellular restriction.
We used multiplex tandem mass tag (TMT)-based whole cell proteomics to perform a …

The Vif protein of human immunodeficiency virus type 1 (HIV-1) promotes viral replication by
downregulation of the cell-encoded, antiviral APOBEC3 proteins. These proteins exert their …

The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to
promote degradation of the APOBEC3 (A3) family of restriction factors. Recently, the cellular …

Viruses are completely dependent upon cellular machinery to support replication and have
therefore developed strategies to co-opt cellular processes to optimize infection and counter …

APOBEC3G belongs to a family of DNA cytosine deaminases that are involved in the
restriction of a broad number of retroviruses including human immunodeficiency virus type 1 …

Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are
mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus …

A diverse set of innate immune mechanisms protects cells from viral infections. The
APOBEC3 family of DNA cytosine deaminases is an integral part of these defenses. For …