Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

VP Torchilin - Nature reviews Drug discovery, 2014 - nature.com
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the
in vivo effectiveness of drugs is now well established. The development of multifunctional …

“Nanoantibiotics”: a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era

AJ Huh, YJ Kwon - Journal of controlled release, 2011 - Elsevier
Despite the fact that we live in an era of advanced and innovative technologies for
elucidating underlying mechanisms of diseases and molecularly designing new drugs …

A molecular imaging primer: modalities, imaging agents, and applications

ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

Advanced materials and processing for drug delivery: the past and the future

Y Zhang, HF Chan, KW Leong - Advanced drug delivery reviews, 2013 - Elsevier
Design and synthesis of efficient drug delivery systems are of vital importance for medicine
and healthcare. Materials innovation and nanotechnology have synergistically fueled the …

Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives

HS El-Sawy, AM Al-Abd, TA Ahmed, KM El-Say… - ACS …, 2018 - ACS Publications
The microenvironment characteristics of solid tumors, renowned as barriers that harshly
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …

Advances in lung cancer treatment using nanomedicines

A Sharma, D Shambhwani, S Pandey, J Singh… - ACS …, 2022 - ACS Publications
Carcinoma of the lungs is among the most menacing forms of malignancy and has a poor
prognosis, with a low overall survival rate due to delayed detection and ineffectiveness of …

Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine

WT Al-Jamal, K Kostarelos - Accounts of chemical research, 2011 - ACS Publications
For decades, clinicians have used liposomes, self-assembled lipid vesicles, as nanoscale
systems to deliver encapsulated anthracycline molecules for cancer treatment. The more …

Liposome-based drug co-delivery systems in cancer cells

SZ Vahed, R Salehi, S Davaran, S Sharifi - Materials Science and …, 2017 - Elsevier
Combination therapy and nanotechnology offer a promising therapeutic method in cancer
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

S Dhar, N Kolishetti, SJ Lippard… - Proceedings of the …, 2011 - National Acad Sciences
Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new
approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to …

Two-stage SN38 release from a core–shell nanoparticle enhances tumor deposition and antitumor efficacy for synergistic combination with immune checkpoint …

X Jiang, M Lee, J **a, T Luo, J Liu, M Rodriguez… - ACS nano, 2022 - ACS Publications
Long-circulating nanomedicines efficiently deliver chemotherapies to tumors to reduce
general toxicity. However, extended blood circulation of nanomedicines can increase drug …