Ski2-like RNA helicases are large multidomain proteins involved in a variety of RNA
processing and degradation events. Recent structures of Mtr4, Ski2 and Brr2 provide our first …

The RNA-processing exosome contains ribonucleases that degrade aberrant RNAs in
archael and eukaryotic cells. In Saccharomyces cerevisiae, the nuclear/nucleolar 3′–5 …

A large body of structural work conducted over the past ten years has elucidated
mechanistic details related to 3′ to 5′ processing and decay of RNA substrates by the …

Next-generation sequencing offers an unprecedented opportunity to jointly analyze cellular
and viral transcriptional activity without prerequisite knowledge of the nature of the …

Mtr4 is a conserved Ski2-like RNA helicase and a subunit of the TRAMP complex that
activates exosome-mediated 3′-5′ turnover in nuclear RNA surveillance and processing …

The packaging of DNA into heterochromatin domains is crucial for gene silencing and
cellular processes, and occurs at centromeres, telomeres and the mating-type locus in …

The regulation of gene expression in a multicellular eukaryotic organism gives rise to
multiple cell types despite having the same organismal genetic code. Early on in our …

Mtr4 is an essential ribonucleic acid (RNA) helicase that plays a central role in RNA
processing and degradation as an activator of the nuclear exosome. Mtr4 can carry out its …

There are numerous RNAs transcribed in the cell that are not directly involved in protein
translation. Maintaining proper levels of RNA is crucial for cell viability, making RNA …

As discussed earlier, none of the human or budding yeast subunits that comprise the 9-
component exosome core retain phosphorolytic exoribonuclease activity because most of …