Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets

JH Dai, XR Tan, H Qiao, N Liu - Protein & Cell, 2024 - academic.oup.com
The profound influence of microbiota in cancer initiation and progression has been under
the spotlight for years, leading to numerous researches on cancer microbiome entering …

Long-distance microbial mechanisms impacting cancer immunosurveillance

L Zitvogel, M Fidelle, G Kroemer - Immunity, 2024 - cell.com
The intestinal microbiota determines immune responses against extraintestinal antigens,
including tumor-associated antigens. Indeed, depletion or gross perturbation of the …

Programmed nanocloak of commensal bacteria-derived nanovesicles amplify strong immunoreactivity against tumor growth and metastatic progression

J Zhang, S Wan, H Zhou, J Du, Y Li, H Zhu, L Weng… - ACS …, 2024 - ACS Publications
Recent discoveries in commensal microbiota demonstrate the great promise of intratumoral
bacteria as attractive molecular targets of tumors in improving cancer treatment. However …

Ultrasound‐activated probiotics vesicles coating for titanium implant infections through bacterial cuproptosis‐like death and immunoregulation

S Li, Y Yue, W Wang, M Han, X Wan, Q Li… - Advanced …, 2024 - Wiley Online Library
Implant‐associated infections (IAIs) are the main cause of prosthetic implant failure.
Bacterial biofilms prevent antibiotic penetration, and the unique metabolic conditions in …

Decomposable nanoagonists enable NIR‐elicited cGAS‐STING activation for tandem‐amplified photodynamic‐metalloimmunotherapy

X Guo, P Tu, X Wang, C Du, W Jiang, X Qiu… - Advanced …, 2024 - Wiley Online Library
Activation of the cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)
pathway has emerged as an efficient strategy to improve the therapeutic outcomes of …

Orally administrated hydrogel harnessing intratumoral microbiome and microbiota-related immune responses for potentiated colorectal cancer treatment

L Li, S He, B Liao, M Wang, H Lin, B Hu, X Lan, Z Shu… - Research, 2024 - spj.science.org
The intestinal and intratumoral microbiota are closely associated with tumor progression and
response to antitumor treatments. The antibacterial or tumor microenvironment (TME) …

Fusobacterium nucleatum carcinogenesis and drug delivery interventions

Z Chen, L Huang - Advanced Drug Delivery Reviews, 2024 - Elsevier
The microbiome has emerged as a significant biomarker and modulator in cancer
development and treatment response. Recent research highlights the notable role of …

Novel strategies for modulating the gut microbiome for cancer therapy

YS Cho, K Han, J Xu, JJ Moon - Advanced Drug Delivery Reviews, 2024 - Elsevier
Recent advancements in genomics, transcriptomics, and metabolomics have significantly
advanced our understanding of the human gut microbiome and its impact on the efficacy …

Liposomes-enabled cancer chemoimmunotherapy

L Zhang, J Shi, MH Zhu, Y Huang, Q Lu, P Sun… - Biomaterials, 2024 - Elsevier
Chemoimmunotherapy is an emerging paradigm in the clinic for treating several malignant
diseases, such as non-small cell lung cancer, breast cancer, and large B-cell lymphoma …

Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death

J Liang, X Tian, M Zhou, F Yan, J Fan, Y Qin, B Chen… - Biomaterials, 2024 - Elsevier
Necroptotic immunogenic cell death (ICD) can activate the human immune system to treat
the metastasis and recurrence of triple-negative breast cancer (TNBC). However …