Mechanisms of exercise as a preventative measure to muscle wasting
Skeletal muscle is the most abundant tissue in healthy individuals and it has important roles
in health beyond voluntary movement. The overall mass and energy requirements of …
in health beyond voluntary movement. The overall mass and energy requirements of …
Spinal cord lesions
R Rupp - Handbook of clinical neurology, 2020 - Elsevier
A spinal cord injury (SCI) may result in impairments of motor, sensory, and autonomous
functions below the injury level. Worldwide, the prevalence of SCI is 1: 1000 and the …
functions below the injury level. Worldwide, the prevalence of SCI is 1: 1000 and the …
Lifelong physical exercise delays age-associated skeletal muscle decline
S Zampieri, L Pietrangelo, S Loefler… - … Series A: Biomedical …, 2015 - academic.oup.com
Aging is usually accompanied by a significant reduction in muscle mass and force. To
determine the relative contribution of inactivity and aging per se to this decay, we compared …
determine the relative contribution of inactivity and aging per se to this decay, we compared …
Long-term high-level exercise promotes muscle reinnervation with age
S Mosole, U Carraro, H Kern, S Loefler… - … of Neuropathology & …, 2014 - academic.oup.com
The histologic features of aging muscle suggest that denervation contributes to atrophy, that
immobility accelerates the process, and that routine exercise may protect against loss of …
immobility accelerates the process, and that routine exercise may protect against loss of …
Electrical stimulation counteracts muscle decline in seniors
H Kern, L Barberi, S Löfler, S Sbardella… - Frontiers in aging …, 2014 - frontiersin.org
The loss in muscle mass coupled with a decrease in specific force and shift in fiber
composition are hallmarks of aging. Training and regular exercise attenuate the signs of …
composition are hallmarks of aging. Training and regular exercise attenuate the signs of …
Home-based functional electrical stimulation rescues permanently denervated muscles in paraplegic patients with complete lower motor neuron lesion
H Kern, U Carraro, N Adami, D Biral… - … and neural repair, 2010 - journals.sagepub.com
Background. Spinal cord injury causes muscle wasting and loss of function, which are
especially severe after complete and permanent damage to lower motor neurons. In a …
especially severe after complete and permanent damage to lower motor neurons. In a …
Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics
S Zampieri, C Mammucari, V Romanello… - Physiological …, 2016 - Wiley Online Library
Age‐related sarcopenia is characterized by a progressive loss of muscle mass with decline
in specific force, having dramatic consequences on mobility and quality of life in seniors. The …
in specific force, having dramatic consequences on mobility and quality of life in seniors. The …
Atrophy, ultra-structural disorders, severe atrophy and degeneration of denervated human muscle in SCI and Aging. Implications for their recovery by Functional …
H Kern, C Hofer, S Loefler, S Zampieri… - Neurological …, 2017 - Taylor & Francis
Objectives: Long-term lower motor neuron denervation of skeletal muscle is known to result
in degeneration of muscle with replacement by adipose and fibrotic tissues. However, long …
in degeneration of muscle with replacement by adipose and fibrotic tissues. However, long …
[HTML][HTML] Persistent muscle fiber regeneration in long term denervation. past, present, future
U Carraro, S Boncompagni, V Gobbo… - European journal of …, 2015 - ncbi.nlm.nih.gov
Despite the ravages of long term denervation there is structural and ultrastructural evidence
for survival of muscle fibers in mammals, with some fibers surviving at least ten months in …
for survival of muscle fibers in mammals, with some fibers surviving at least ten months in …
Mitochondrial health and muscle plasticity after spinal cord injury
AS Gorgey, O Witt, L O'Brien, C Cardozo… - European Journal of …, 2019 - Springer
Mitochondria are responsible for aerobic respiration and large-scale ATP production in
almost all cells of the body. Their function is decreased in many neurodegenerative and …
almost all cells of the body. Their function is decreased in many neurodegenerative and …